Last update
3/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
Most Useful Reviews
9
Increased strength
3 people found this helpful
I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.
Read More
9
Balanced levels
3 people found this helpful
Niacin has significantly helped improve my blood glucose, cholesterol, and homocysteine levels. I found the 250-500 mg dosage ideal. The slow-release formula with inositol is effective for my mum, sister, and me. It’s working well for us.
Read More
0
No noticeable effects
Niacin is said to benefit those worried about blood flow and beauty. Despite my curiosity, I found no taste and easy consumption. I've been taking it daily for three months but noticed no effects. After careful research and concern about side effects, I stopped using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased strength
3 people found this helpful
I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.
Read More
9
Balanced levels
3 people found this helpful
Niacin has significantly helped improve my blood glucose, cholesterol, and homocysteine levels. I found the 250-500 mg dosage ideal. The slow-release formula with inositol is effective for my mum, sister, and me. It’s working well for us.
Read More
0
No noticeable effects
Niacin is said to benefit those worried about blood flow and beauty. Despite my curiosity, I found no taste and easy consumption. I've been taking it daily for three months but noticed no effects. After careful research and concern about side effects, I stopped using it.
Read More
Frequently Asked Questions
9
Increased strength
3 people found this helpful
I've been taking this product daily for two months, and I feel great! My blood circulation has improved significantly, and my body feels pleasantly warm. Despite long work hours, I've managed to maintain my stamina. My skin and hair have also become noticeably healthier, especially when taken with vitamin C. Overall, it's been a positive addition to my routine as I’m over 40.
0
No noticeable effects
Niacin is said to benefit those worried about blood flow and beauty. Despite my curiosity, I found no taste and easy consumption. I've been taking it daily for three months but noticed no effects. After careful research and concern about side effects, I stopped using it.
9
Balanced levels
3 people found this helpful
Niacin has significantly helped improve my blood glucose, cholesterol, and homocysteine levels. I found the 250-500 mg dosage ideal. The slow-release formula with inositol is effective for my mum, sister, and me. It’s working well for us.
9
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
References
- Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, et al. A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. J Thromb Haemost. 2019;17:2110. 10.1111/jth.14606
